Glimepirde (Amaryl)

Glimepirde (Amaryl)

Glimepirde (Amaryl).pptx

목차 History of sulfonyurea Mechanism of drug action SAR study Synthesis of Glimepiride Clinical Trials Glimepiride & Marketing Reference 본문 History of sulfonylurea IPTP for typhoid fever(장티푸스) in early 1940s Many patients died. – acute & prolonged hypoglycemia Carbutamide effective oral hypoglycemic Firtst sulfonyluea hypoglycemic 본문내용 ver(장티푸스) in early 1940s Many patients died.acute & prolonged hypoglycemia Carbutamide effective oral hypoglycemic Firtst sulfonyluea hypoglycemic History of sulfonylurea Mechanism of drug action Mechanism of drug action Insulin secretion Mechanism of drug action Mechanism of drug action Mechanism of drug action Target structureKATP channel Mechanism of drug action Interaction between d 참고문헌 http://www.drugs.com/pro/amaryl.html http://dric.sookmyung.ac.kr/NEWS/sep97/newdrug.htm 사노피 공식 배포자료 임상시험의 통계학적 방법 대한간질학회지 2006;10(2):71-77 명성민김신영 Overview of Current Therapeutic Options in Type 2 Diabetes John B. Buse, MD, PHD http://www.doctorsnews.co.kr/news/articleView.html?idxno=82623 Medical chemistry. New Age international publishers. Ashutosh Kar 2011 의약품산업 분석보고서. KHIDI 한국보건산업진흥원 The Molecular Mechanism of the Insulin-mimetic/sensitizing Activity of the AntidiabeticSulfonylurea Drug Amaryl.Günter Müller.Aventis Pharma Germany, Frankfurt, Germany. Accepted August 8, 2000. Defining a binding pocket for sulfonylureas in ATP-sensitive potassium channels. Wanda H. Vila-Carriles*, Guiling Zhao† and Joseph Bryan† A Transmembrane Domain of the Sulfonylurea Receptor Mediates Activation of ATP-Sensitive K+ Channels by K+Channel Openers . Nathalie D’hahan, Hélène Jacquet, Christophe Moreau, Patrice Catty and Michel Vivaudou